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. 2023 Oct 5;14:1274791. doi: 10.3389/fendo.2023.1274791

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Copyright © 2023 Roshandel, Lu, Paterson and Dash

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Graphical presentation of the study. Sex-stratified GWAS of body fat percentage adjusted for a number of covariates (BFPAdj) were performed in 157,937 males and 154,337 females from the UK Biobank. Independent GWS BFPAdj loci were investigated for association with T2D (21), CAD (22), HDL (23), TG (23) and MRI-derived regional fat depots (10) using publicly available summary statistics from their corresponding largest meta-GWAS. Two-sample Mendelian randomization (MR) was used to investigate the causal association of BFPAdj with T2D, CAD, HDL and TG using summary statistics from the current GWAS of BFPAdj and publicly available summary statistics from the largest meta-GWAS of T2D (21), CAD (22), HDL and TG (23).