TABLE 1.

Activities of LY303366, fluconazole, ketoconazole, itraconazole, 5FC, and amphotericin B against yeast species isolated from the lower gastrointestinal tract of seriously ill patients

Yeast (no. of isolates)	Antifungal agent	MIC (μg/ml)
		50%	90%	Range
C. albicans (413)	LY303366	0.125	0.25	≤0.0313–0.25
	Fluconazole	0.125	0.25	≤0.0313–8
	Ketoconazole	≤0.0313	0.125	≤0.0313–1
	Itraconazole	0.125	0.25	≤0.0313–1
	5FC	0.125	0.5	≤0.0313–>64
	Amphotericin B	0.25	0.5	0.0625–0.5
C. glabrata (275)	LY303366	0.25	0.5	≤0.0313–1
	Fluconazole	8	32	0.5–64
	Ketoconazole	0.25	0.5	≤0.0313–1
	Itraconazole	0.25	1	≤0.0313–2
	5FC	0.0625	0.0625	≤0.0313–2
	Amphotericin B	1	1	0.0625–1
S. cerevisiae (24)	LY303366	1	2	0.25–2
	Fluconazole	0.5	2	≤0.0313–4
	Ketoconazole	0.25	1	≤0.0313–2
	Itraconazole	0.25	2	≤0.0313–4
	5FC	0.0625	0.25	≤0.0313–0.5
	Amphotericin B	1	1	0.125–1
C. parapsilosis (18)	LY303366	4	4	2–8
	Fluconazole	0.25	0.5	0.0625–1
	Ketoconazole	0.0625	0.25	≤0.0313–0.25
	Itraconazole	0.125	0.25	≤0.0313–0.5
	5FC	0.0625	0.125	≤0.0313–0.5
	Amphotericin B	1	1	0.25–1
C. tropicalis (15)	LY303366	0.5	1	0.125–1
	Fluconazole	0.5	4	0.0625–>64
	Ketoconazole	0.0625	0.125	≤0.0313–2
	Itraconazole	0.25	0.5	0.0625–8
	5FC	0.125	0.25	0.0625–64
	Amphotericin B	1	1	0.5–1
C. lusitaniae (10)	LY303366	0.5	2	0.125–2
	Fluconazole	0.25	0.5	0.125–1
	Ketoconazole	0.0625	0.25	≤0.0313–0.25
	Itraconazole	0.25	0.25	0.0625–0.25
	5FC	≤0.0313	0.0625	≤0.0313–0.125
	Amphotericin B	1	1	0.5–1
C. krusei (8)	LY303366			0.5–1
	Fluconazole			4–32
	Ketoconazole			0.125–2
	Itraconazole			0.5–4
	5FC			0.5–32
	Amphotericin B			0.5–1
R. rubra (4)	LY303366			32
	Fluconazole			0.125–>64
	Ketoconazole			0.125–0.5
	Itraconazole			0.25–0.5
	5FC			≤0.0313–0.25
	Amphotericin B			0.5–1
C. kefyr (3)	LY303366			0.25–0.5
	Fluconazole			0.125–0.25
	Ketoconazole			≤0.0313–0.125
	Itraconazole			0.25–0.5
	5FC			0.0625
	Amphotericin B			1