Table 3.

Decreased bioavailable L-arginine is associated with markers of intestinal barrier dysfunction.

Linear regression models of the association between log-transformed concentrations of components of the L-arginine bioavailability axis (L-arginine, ADMA, SDMA, and L-arginine:ADMA ratio; predictor variables) and log-transformed concentrations of sCD14 and LBP (outcome variables). All variables were quantified from enrolment plasma samples at gestational age <24 weeks. n = 331. Data are presented as results of both simple linear regression analyses (unadjusted) and multivariable linear regression analyses adjusted for enrolment P. falciparum PCR status, maternal age, gestational age, BMI, and socioeconomic status. Statistically significant relationships (p < 0.05) are bolded. Cell shade indicates the magnitude of the β coefficient for statistically significant relationships according to the scale (right). sCD14: soluble CD14; LBP: lipopolysaccharide binding protein; ADMA: asymmetric dimethyl arginine; SDMA: symmetric dimethyl arginine; C.I.: confidence interval.