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. 2023 Oct 5;14:1242536. doi: 10.3389/fimmu.2023.1242536

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Copyright © 2023 Peterhoff, Wiegrebe, Einhauser, Patt, Beileke, Günther, Steininger, Niller, Burkhardt, Küchenhoff, Gefeller, Überla, Heid and Wagner

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antigen-specific changes of avidity over time. (A) Avidity index (AI) of serum IgG directed against S ecto, S RBD, N NTD, and N CTD observed at baseline, first and second follow-up visit 5 and 10 months after baseline (BL, FU1 and FU2, respectively): for each of the three time points, we show the distribution of values (box: 1^st quartile, median and 3^rd quartile; whiskers 5^th and 95^th percentile; dots below and above the whiskers refer to observed values outside the 5^th and 95^th percentile) and p-values from Wilcoxon signed-rank test. (B) Proportional changes in the AI at first or second follow-up (FU1, FU2) compared to BL (in percent). For each of the three time points, we show individual changes in avidity at FU1 and FU2 compared to BL (% BL). The dashed line represents the 100% BL level (i.e. no change), horizontal solid lines show the median values, and the median change is stated as % for each follow-up time point compared to BL.