Table 4.
Univariate and multivariate logistic analysis for identifying surgical benefit-related variables in BC patients with BM.
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| OR | 95%CI | p-value | OR | 95%CI | p-value | |
| Age | ||||||
| < 60 years | Reference | |||||
| ≥ 60 years | 0.757 | 0.584-0.981 | 0.036 | |||
| Race | ||||||
| African American | Reference | Reference | ||||
| Other | 1.548 | 0.857-2.796 | 0.148 | 1.412 | 0.765-2.605 | 0.270 |
| Caucasian populations | 2.128 | 1.482-3.057 | <0.001 | 2.017 | 1.377-2.954 | <0.001 |
| Sex | ||||||
| Female | Reference | |||||
| Male | 3.702 | 0.743-18.441 | 0.110 | |||
| Laterality | ||||||
| Left | Reference | |||||
| Right | 0.857 | 0.661-1.111 | 0.245 | |||
| Grade | ||||||
| I | Reference | |||||
| II | 0.795 | 0.499-1.268 | 0.336 | |||
| III | 0.469 | 0.295-0.748 | 0.001 | |||
| IV | 0.002 | 0.001-0.003 | 1.000 | |||
| T stage | ||||||
| T1-2 | Reference | Reference | ||||
| T3-4 | 0.674 | 0.519-0.875 | 0.003 | 0.736 | 0.559-0.970 | 0.029 |
| N stage | ||||||
| N0 | Reference | |||||
| N1-3 | 0.778 | 0.564-1.074 | 0.127 | |||
| Primary site | ||||||
| Central portion of breast | Reference | |||||
| Lower-inner | 1.053 | 0.453-2.444 | 0.905 | |||
| Lower-outer | 1.228 | 0.568-2.653 | 0.601 | |||
| Upper-inner | 0.992 | 0.518-1.902 | 0.982 | |||
| Upper-outer | 0.847 | 0.510-1.406 | 0.520 | |||
| Other | 0.795 | 0.491-1.286 | 0.349 | |||
| Histology | ||||||
| Ductal | Reference | |||||
| Lobular | 0.995 | 0.661-1.497 | 0.980 | |||
| Other | 0.752 | 0.505-1.121 | 0.162 | |||
| Breast subtype | ||||||
| HR+/HER2- | Reference | Reference | ||||
| HR+/HER2+ | 1.301 | 0.898-1.885 | 0.164 | 1.571 | 1.065-2.318 | 0.023 |
| HR-/HER2+ | 0.657 | 0.378-1.142 | 0.137 | 0.948 | 0.531-1.694 | 0.858 |
| HR-/HER2- | 0.184 | 0.102-0.331 | <0.001 | 0.234 | 0.128-0.427 | <0.001 |
| Tumor size | ||||||
| < 5 cm | Reference | |||||
| 5-10 cm | 0.722 | 0.546-0.955 | 0.022 | |||
| > 10 cm | 0.437 | 0.249-0.766 | 0.004 | |||
| Lung metastasis | ||||||
| No | Reference | |||||
| Yes | 0.703 | 0.506-0.978 | 0.036 | |||
| Liver metastasis | ||||||
| No | Reference | Reference | ||||
| Yes | 0.483 | 0.336-0.696 | <0.001 | 0.510 | 0.346-0.752 | 0.001 |
| Brain metastasis | ||||||
| No | Reference | Reference | ||||
| Yes | 0.457 | 0.218-0958 | 0.038 | 0.400 | 0.179-0.894 | 0.026 |
| Surgery to DM | ||||||
| No | Reference | |||||
| Yes | 1.447 | 0.761-2.754 | 0.260 | |||
| Radiotherapy | ||||||
| No | Reference | Reference | ||||
| Yes | 1.373 | 1.052-1.792 | 0.020 | 1.527 | 1.147-2.032 | 0.004 |
| Chemotherapy | ||||||
| No | Reference | |||||
| Yes | 0.994 | 0.765-1.291 | 0.961 | |||