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Experimental timeline and design. The impact of acute oral administration of saffron extract (6.25 mg/kg) was measured on behavioral (sickness behavior, splash-test), neuroinflammatory (brain expression of inflammatory factors) and neurobiological (KYN and BH4 pathways, monoamine systems) alterations induced by a lipopolysaccharide challenge (LPS, 830 μg/kg, ip). n = 14 mice/group.
