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. 2023 Oct 5;10:1267839. doi: 10.3389/fnut.2023.1267839

Figure 2.

Figure 2

Effects of oral saffron extract administration (6.25 mg/kg) on LPS-induced sickness behavior (830 μg/kg, ip). (A) Body weight (g) measured 30 min before LPS injection (T0) and 5 h30 and 23 h after; (B) Food intake (g) measured 5 h30 and 23 h after LPS injection; (C) Total sickness score assessed 5 h30 and 23 h after LPS injection; (D) Delta sickness scores (between the two timepoints) in LPS-treated groups; (E) Latency to groom (sec) and (F) Duration of grooming (sec) in the splash-test conducted 5 h30 after LPS injection. Results are shown as mean ± SEM. * p ≤ 0.05, *** p ≤ 0.001 vs. Control; # p ≤ 0.05 vs. LPS.