TABLE 1.
ID50s for staphylococcal strains in guinea pigs receiving different prophylactic regimens
| Regimen | ID50 (CFU) of straina
|
||
|---|---|---|---|
| 3094 (BSSA) | 5030 (MRSA) | 9021 (MRSE) | |
| Placebo | 0.5 | 0.8 | 1.9 |
| PGG-glucan | 18 | 17 | 23 |
| Cefazolin | 315 | 220 | 212 |
| PGG-glucan–cefazolin | 2,468 | 2,642 | 4,256 |
a
ID50s are calculated from the results of the logistic regression equation. Abbreviations: BSSA, borderline susceptible S. aureus; MRSA, methicillin-resistant S. aureus; MRSE, methicillin-resistant S. epidermidis. For each staphylococcal strain, significant differences among the four prophylactic regimens were obtained by logistic regression analysis (P < 0.0001).