Table 4.
Parameters of COVID-19 hospital patients divided by age: 69 years.
| Parameter |
older COVID-19 patients (≥69 y) |
p-value | younger COVID-19 patients (<69 y) |
p-value | ||
|---|---|---|---|---|---|---|
| Controls |
COVID-19 |
Controls |
COVID-19 |
|||
| Subjects | n = 24 | n = 24 | n = 24 | n = 24 | ||
| DNA damage parameters | ||||||
| Lysis (% Tail DNA) | 1.80 ± 0.46 | 1.89 ± 0.60 | 0.702 | 1.75 ± 0.62 | 2.17 ± 0.85 | 0.048 |
| Netto FPG (% Tail DNA) | 7.59 ± 1.90 | 7.67 ± 2.36 | 0.898 | 8.12 ± 2.73 | 10.69 ± 6.50 | 0.055 |
| H2O2 (% Tail DNA) | 11.87 ± 2.93 | 12.51 ± 3.43 | 0.686 | 11.02 ± 2.70 | 12.37 ± 2.35 | 0.035 |
| Oxidative stress parameters | ||||||
| FRAP (μmol/L) | 989 ± 218 | 995 ± 319 | 0.684 | 976 ± 241 | 917 ± 199 | 0.452 |
| GSH (μmol/L) | 14.27 ± 2.84 | 13.81 ± 2.50 | 0.585 | 16.01 ± 2.88 | 14.91 ± 4.68 | 0.051 |
| GSSG (μmol/L) | 9.33 ± 2.60 | 7.84 ± 2.43 | 0.026 | 11.20 ± 2.23 | 8.52 ± 4.87 | <0.001 |
| GSH/GSSG ratio | 1.68 ± 0.66 | 1.89 ± 0.59 | 0.127 | 1.47 ± 0.37 | 2.20 ± 1.65 | 0.037 |
| MDA (μmol/L) | 1.52 ± 0.36 | 1.50 ± 0.54 | 0.621 | 1.58 ± 0.44 | 1.61 ± 0.62 | 0.853 |
| Blood parameters | ||||||
| hs-CRP (mg/L) | 1.93 ± 2.70 | 74.99 ± 75.28 | <0.001 | 2.08 ± 1,97 | 78.94 ± 70.03 | <0.001 |
| UCB (μmol/L) | 3.89 ± 3.49 | 3.10 ± 4.18 | 0.234 | 3.72 ± 2.12 | 2.20 ± 1.65 | <0.001 |
| Vitamin D (ng/ml) | 23.00 ± 6.95 | 23.45 ± 12.62 | 0.984 | 21.72 ± 11.14 | 21.75 ± 12.50 | 0.711 |
Data are presented as means ± standard deviation, p-values are calculated using Mann-Whitney U test for measuring age differences, significant differences are highlighted with bold numbers. A p-value (p) of 0.05 is considered as significant. Older healthy and older COVID-19 hospital patients are age and sex-matched. FPG: ormamidopyrimidine DNA glycosylase, FRAP: ferric rducing bility potential; GSH: γ-glutamyl-cysteinyl-glycine; GSSG: glutathione disulfide; MDA: malondialdehyde; hs-CRP: igh ensitivity c-reactive protein; ALAT: alanine-minotransferase; ASAT: aspartate-aminotransferase, UCB: nconjugated ilirubin; HDL: igh density lipoprotein; LDL: olow density lipoprotein.