Table 3.
Perioperative factor replacement therapy in function of the surgery type and the severity of factor deficiency.
| Severe deficiencies (coagulation factor level ≤10%) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Orthopedic surgery |
TA (%) | Gynecology/ obstetrical surgery |
TA (%) | Tooth extraction |
TA (%) | Digestive surgery |
Maxillofacial and ENT surgery |
Miscellaneous surgery |
|||||||
| N | Untreated (%) | N | Untreated (%) | N | Untreated (%) | N | Untreated (%) | N | Untreated (%) | N | Untreated (%) | |||||
| All deficiencies | 81 | 15 | 1 (6.7) | 6 (40.0) | 19 | 7 (36.8) | 5 (26.3) | 13 | 10 (76.9) | 11 (84.6) | 10 | 3 (30.0) | 4 | 2 (50.0) | 20 | 4 (20.0) |
| F VII | 51 | 9 | 0 | 1 | 11 | 1 | 0 | 7 | 5 | 7 | 8 | 2 | 3 | 2 | 13 | 2 |
| F XI | 24 | 5 | 1 | 5 | 8 | 6 | 5 | 4 | 3 | 3 | 1 | 1 | 0 | 0 | 6 | 2 |
| F V | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| F V+VIII | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
| F X | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
| F II | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Mild deficiencies (coagulation factor level >10%) | ||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| N | Orthopedic surgery |
TA (%) | Gynecology/ obstetrical surgery |
TA (%) | Tooth extraction |
TA (%) | Digestive surgery |
Maxillofacial and ENT surgery |
Miscellaneous surgery |
|||||||
| N | Untreated (%) | N | Untreated (%) | N | Untreated (%) | N | Untreated (%) | N | Untreated (%) | N | Untreated (%) | |||||
| All deficiencies | 126 | 20 | 13 (65) | 4 (20.0) | 30 | 26 (86.7) | 11 (36.7) | 21 | 20 (95.2) | 16 (76.2) | 15 | 11 (73.3) | 15 | 13 (86.7) | 25 | 18 (72.0) |
| F VII | 67 | 8 | 4 | 1 | 16a | 14 | 6 | 11 | 11 | 6 | 9 | 7 | 8 | 6 | 15 | 11 |
| F XI | 40 | 8 | 7 | 3 | 9 | 7 | 5 | 7 | 6 | 7 | 4 | 2 | 5 | 5 | 7 | 5 |
| F V | 13 | 1 | 1 | 0 | 4 | 4 | 0 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| F V+VIII | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | ||||
| F X | 4 | 2 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | |
| F II | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | ||||
ENT, Ear Nose Throat; Untreated, no perioperative factor replacement (tranexamic acid may have been used)
a
All FVII:C levels correspond to baseline levels measured at distance from pregnancy except for one. In this patient FVII:C level was 46%, but the patient was lost to follow-up and the baseline FVII:C level may have been different.