Table 5.
Characteristics of the patients with excessive bleeding after surgery. All excessive postoperative bleeding events are listed, and the 3 cases in which postoperative bleeding was excessive are highlighted in bold.
| Patient (age, y) | Factor level | Procedure | Bleeding score (Tosetto’s) | Perioperative factor replacement | Bleeding | Comments |
|---|---|---|---|---|---|---|
| 1 (65) | FVII:C = 1% | Left lung lobectomy | 4 | rFVIIa | Spontaneous spleen rupture at day 4 postsurgery | No bleeding complication at the lobectomy site |
| 2 (89) | FVII:C = 5% | Nephrectomy | 2 | rFVIIa | Pseudoaneurysm of the radial artery following catheterization | Cataract surgery performed afterward without factor replacement, no bleeding |
| 3 (79) | FVII:C = 9% | Total knee prosthesis | 7 | rFVIIa | Bruises at the arms | No bleeding at the surgery site |
| 4 (81) | FXI:C = 10% | Total hip prosthesis | 0 | pd-FXI (at higher doses than recommended∗) | Excessive bleeding immediately after surgery and between 24 and 72 h | Platelet and red blood cell transfusions |
| 5 (13) | FV:C = 10% FVIII:C = 10% | Tonsillectomy | 0 | FFP and TA | Excessive bleeding at day 7 postsurgery | Treatment changed to FVIII concentrate and FFP from day 7 to day 16 |
| 6 (34) | FVII:C = 33% | Ectopic pregnancy | 10 | No treatment | Hemoperitoneum | Previous uterine curettage without bleeding and without factor replacement |
FVII:C, factor VII activity level; FXI:C, factor XI activity level; pd-FXI, plasma-derived factor XI concentrate; rFVIIa, recombinant activated factor VII; FFP, fresh frozen plasma; TA, tranexamic acid.