Table 3.
Haematological and biochemical parameters assessed in Wistar rats orally administered with 1000 mg/kg of PHF for acute toxicity at 14 days after administration.
| Parameters | Control (n = 3) | PHF (n = 3) | P value |
|---|---|---|---|
| Haematological changes | |||
| WBC (103/μL) | 7.63 ± 1.41 | 8.60 ± 0.43 | P = 0.322 |
| RBC (106/μL) | 10.35 ± 0.22 | 9.33 ± 0.71 | P = 0.078 |
| Hemoglobin (g/dl) | 15.33 ± 0.25 | 14.73 ± 0.76 | P = 0.266 |
| HCT (%) | 47.73 ± 0.23 | 46.03 ± 2.25 | P = 0.264 |
| MCV (fL) | 46.06 ± 1.16 | 45.63 ± 1.95 | P = 0.758 |
| MCH (pg) | 14.76 ± 0.20 | 13.83 ± 0.87 | P = 0.146 |
| MCHC (g/dl) | 32.06 ± 0.55 | 31.46 ± 1.74 | P = 0.601 |
| MPV (fL) | 5.86 ± 0.05 | 6.20 ± 0.55 | P = 0.361 |
| RDW (%) | 16.70 ± 0.10 | 16.40 ± 1.32 | P = 0.715 |
| Platelets (103/μL) | 673.60 ± 50.46 | 673.30 ± 109.50 | P = 0.996 |
| Biochemical changes | |||
| Alanine Transaminase (IU/l) | 41.80 ± 8.00 | 57.80 ± 15.10 | P = 0.181 |
| Alkaline Phosphatase (IU/l) | 94.80 ± 21.70 | 151.60 ± 48.40 | P = 0.138 |
| Albumin (g/dl) | 6.03 ± 2.10 | 6.80 ± 1.90 | P = 0.648 |
| Creatinine (mg/dl) | 0.50 ± 0.20 | 0.63 ± 0.30 | P = 0.561 |
Values expressed as mean ± SD. Significance with one way ANOVA analysis is evaluated as p ≤ 0.05. Note: WBC – white blood cell count, HCT – haematocrit, MCV – mean corpuscular volume, MCH – mean corpuscular haemoglobin, MCHC – mean corpuscular haemoglobin concentration, RDW – red cell distribution width, and MPV – mean platelet volume.