Table 5.
Haematological and biochemical parameters assessed in Wistar rats orally administered with 1000 mg/kg of PHF in satellite group toxicity for 28 days and follow up of 14 days.
| Parameters | Sex/n | Control | PHF 1000 mg/kg | P Value |
|---|---|---|---|---|
| Hematological changes | ||||
| WBC (103/uL) | M (n = 3) | 7.33 ± 3.04 | 7.4 ± 1.67 | |
| F (n = 3) | 6.53 ± 0.60 | 6.73 ± 2.32 | ||
| T (n = 6) | 6.93 ± 2.01 | 7.06 ± 1.84 | P = 0.907 | |
| RBC (106/uL) | M (n = 3) | 10.33 ± 0.28 | 10.23 ± 0.26 | |
| F (n = 3) | 10.69 ± 0.49 | 10.40 ± 1.43 | ||
| T (n = 6) | 10.51 ± 0.41 | 10.32 ± 0.93 | P = 0.660 | |
| Hemoglobin (gram%) | M (n = 3) | 15.10 ± 0.75 | 14.76 ± 0.68 | |
| F (n = 3) | 15.50 ± 0.30 | 15.4 ± 2.08 | ||
| T (n = 6) | 15.25 ± 0.58 | 15.08 ± 1.42 | P = 0.797 | |
| HCT (%) | M (n = 3) | 48.33 ± 0.97 | 47.00 ± 2.28 | |
| F (n = 3) | 40.03 ± 1.95 | 48.90 ± 6.1 | ||
| T (n = 6) | 48.68 ± 1.43 | 47.95 ± 4.25 | P = 0.697 | |
| MCV (fL) | M (n = 3) | 46.73 ± 0.37 | 45.83 ± 1.51 | |
| F (n = 3) | 45.83 ± 0.25 | 45.33 ± 2.59 | ||
| T (n = 6) | 46.28 ± 0.57 | 46.43 ± 1.29 | P = 0.801 | |
| MCH (pg) | M (n = 3) | 14.20 ± 0.86 | 14.33 ± 0.3 | |
| F (n = 3) | 14.13 ± 0.25 | 14.73 ± 0.35 | ||
| T (n = 6) | 14.46 ± 0.36 | 14.53 ± 0.36 | P = 0.758 | |
| MCHC (g/dl) | M (n = 3) | 30.93 ± 1.00 | 31.4 ± 0.95 | |
| F (n = 3) | 31.56 ± 0.65 | 31.43 ± 0.45 | ||
| T (n = 6) | 31.25 ± 0.83 | 31.41 ± 0.66 | P = 0.711 | |
| MPV (fL) | M (n = 3) | 6.41 ± 0.34 | 5.76 ± 0.05 | |
| F (n = 3) | 6.30 ± 0.45 | 6.76 ± 0.55 | ||
| T (n = 6) | 6.35 ± 0.36 | 6.26 ± 0.65 | P = 0.790 | |
| RDW (%) | M (n = 3) | 15.30 ± 0.43 | 16.66 ± 0.23 | |
| F (n = 3) | 17.36 ± 0.25 | 16.76 ± 0.55 | ||
| T (n = 6) | 16.33 ± 1.17 | 16.71 ± 0.38 | P = 0.465 | |
| Platelets (103/uL) | M (n = 3) | 679.60 ± 22.5 | 630.30 ± 72.15 | |
| F (n = 3) | 656.00 ± 49.15 | 535.00 ± 281.10 | ||
| T (n = 6) | 667.80 ± 36.56 | 582.61 ± 190.80 | P = 0.308 | |
| Biochemical changes | ||||
| Alanine transaminase (IU/l) | M (n = 3) | 47.83 ± 12.87 | 48.56 ± 8.05 | |
| F (n = 3) | 55.83 ± 19.70 | 45.66 ± 19.91 | ||
| T (n = 6) | 51.81 ± 15.52 | 47.1 ± 13.63 | P = 0.589 | |
| Alkaline phosphatase (IU/l) | M (n = 3) | 85.45 ± 37.01 | 126.2 ± 30.90 | |
| F (n = 3) | 154.20 ± 57.41 | 106.62 ± 21.72 | ||
| T (n = 6) | 132.6 ± 43.30 | 116.4 ± 26.23 | P = 0.712 | |
| Albumin (g/dl) | M (n = 3) | 6.03 ± 0.15 | 5.23 ± 2.41 | |
| F (n = 3) | 4.23 ± 0.75 | 4.83 ± 1.60 | ||
| T (n = 6) | 5.11 ± 1.11 | 5.03 ± 1.84 | P = 0.902 | |
| Creatinine (mg/dl) | M (n = 3) | 0.61 ± 0.51 | 0.40 ± 0.21 | |
| F (n = 3) | 0.84 ± 0.42 | 0.70 ± 0.41 | ||
| T (n = 6) | 0.73 ± 0.40 | 0.55 ± 0.34 | P = 0.471 | |
Values expressed as mean ± SD. Significance with One way ANOVA analysis is evaluated as p ≤ 0.05. Note: F – female, M− male, T – total, WBC – white blood cell count, HCT – haematocrit, MCV – mean corpuscular volume, MCH – mean corpuscular haemoglobin, MCHC – mean corpuscular haemoglobin concentration, RDW – red cell distribution width, and MPV – mean platelet volume.