Figure 1.
Flow chart of the data analysis
The figure summarizes the main procedures and steps in the entire data analysis; the left panel illustrates the analytical steps for the identification (ID) of pharmacodynamic (PD) modules, while the right panel shows the validation of plasma cell (PC) as PD module associated with the disease. BL: baseline; W48: week 48; FaSS: FaSScinate; PC: plasma cells; PD: pharmacodynamic; PBO: placebo group; TCZ: the group of treatment with tocilizumab; WGCNA: weighted gene co-expression network analysis.