Figure 3.

PC signature is down-regulated by TCZ treatment in FaSScinate cohort

(A) PC signature is down-regulated in TCZ treatment arm compared with placebo arm. The eigengene change of 3-gene PC signature 24 weeks post treatment from pretreatment is expressed on y axis and p value labeled on the top of graph is from Wilcoxon test.

(B) Additional test with ANCOVA model confirmed the significant down-regulation of PC signature by TCZ treatment and the greater PD effects on the subjects with higher PC expression level. Scatterplot shows the function of change (follow-up/baseline measurements) against baseline measurements, both in log10. The dotted line represents perfect agreement (no change) and the dashed lines are fitted regression lines for TCZ treatment and placebo groups. P value was from ANCOVA test.