Figure 6.

Skin PC signature enriched in IPF ILD lungs

(A) Relationship between WGCNA derived module eigengenes from RNAseq of IPF lung. (a) The eigengene dendrogram of DEG genes on hierarchical clustering of adjacency-based dissimilarity, and (b) relationship of modules on eigengene adjacency heatmap depicted tight clusters of correlated eigengenes of modules. The modules assigned in WGCNA, were either text labeled in (a) or color labeled on both axes of the heatmap in (b), respectively. Colors in heatmap are from low adjacency (blue) to high adjacency (red).

(B) Heatmap showing the overall results from overlap analysis between the module genes from IPF lung and PD modules from SSc skin. Blue color gradient represents the score of odds ratios. The number on the top in each square box of heatmap represents the odds ratio of overlapping from the analysis, while the number in parentheses at the bottom represents the p value in -log10. The color labeled modules derived from the RNAseq of IPF lung are present on x axis and 4 PD modules from skin RNAseq are on y axis. ns represents no statistical significance with a cutoff of p < 0.05.

(C) PC ME in control and ILD lungs. PC MEs of SSc and IPF lungs were compared to each other and to controls (n = 20 in each category as shown). P value shown on the top of plot was derived from Wilcoxon test.