Table 1.
Characterization of demographics of subjects in comparison between RNAseq subset and the total cohort of FocuSSced
| Comparison of population characteristics between subjects in the total cohort and RNAseq subset | |||
|---|---|---|---|
| RNAseq subset | Total cohort | p value | |
| N | 37 | 208 | |
| Age (mean (SD)) | 51.27 (11.25) | 48.09 (12.43) | n.s. |
| FVC%pred. (median [IQR]) | 81.35 [70.19, 93.44] | 82.48 [71.12, 93.30] | n.s. |
| FVC change (median [IQR]) | −0.05 [-0.16, 0.06] | −0.05 [-0.12, 0.06] | n.s. |
| DLCO%pred. (median [IQR]) | 74.29 [57.28, 89.30] | 73.63 [63.21, 88.28] | n.s. |
| DLCO change (median [IQR]) | −0.09 [-0.23, 0.01] | −0.05 [-0.17, 0.09] | n.s. |
| MRSS (median [IQR]) | 22.00 [17.00, 30.00] | 19.00 [15.00, 25.00] | ∗ |
| MRSS change (median [IQR]) | −0.11 [-0.20, −0.01] | −0.12 [-0.20, −0.02] | n.s. |
| Comparison of population characteristics within PBO arm | |||
|---|---|---|---|
| RNAseq subset | Total cohort | p value | |
| n | 19 | 104 | |
| Age (mean (SD)) | 54.05 (10.74) | 49.19 (12.66) | n.s. |
| FVC%pred. (median [IQR]) | 92.13 [81.48, 98.03] | 86.84 [72.56, 95.96] | n.s. |
| FVC change (median [IQR]) | −0.13 [-0.28, −0.03] | −0.08 [-0.16, 0.01] | n.s. |
| DLCO%pred. (median [IQR]) | 76.55 [69.66, 98.06] | 76.15 [65.70, 85.90] | n.s. |
| DLCO change (median [IQR]) | −0.14 [-0.31, −0.03] | −0.06 [-0.18, 0.07] | n.s. |
| MRSS (median [IQR]) | 20.00 [15.50, 29.00] | 19.00 [15.00, 26.00] | n.s. |
| MRSS change (median [IQR]) | −0.05 [-0.19, 0.02] | −0.11 [-0.20, 0.01] | n.s. |
| Comparison of population characteristics within TCZ arm | |||
|---|---|---|---|
| RNAseq subset | Total cohort | p value | |
| n | 18 | 104 | |
| Age (mean (SD)) | 48.33 (11.31) | 46.98 (12.15) | n.s. |
| FVC%pred. (median [IQR]) | 72.89 [66.23, 77.70] | 80.00 [69.69, 90.04] | n.s. |
| FVC change (median [IQR]) | 0.01 [-0.08, 0.18] | −0.02 [-0.10, 0.08] | n.s. |
| DLCO%pred. (median [IQR]) | 60.85 [51.15, 82.33] | 71.46 [59.42, 89.24] | n.s. |
| DLCO change (median [IQR]) | −0.04 [-0.12, 0.11] | −0.05 [-0.17, 0.11] | n.s. |
| MRSS (median [IQR]) | 25.50 [19.00, 30.75] | 19.00 [15.00, 24.25] | ∗∗ |
| MRSS change (median [IQR]) | −0.18 [-0.23, −0.06] | −0.14 [-0.21, −0.06] | n.s. |
n.s.: no significance statistically; ∗∗ p value <0.05.