Table 3. Baseline characteristics and Grades 3-5 adverse effects from randomized controlled trials.
ALT: alanine aminotransferase; AST: aspartate aminotransferase; GGT: Gamma-glutamyltransferase; CK: creatine kinase
| Study | Study design | Number of patients in the crizotinib group | Number of patients in the corresponding group (different treatment or no treatment) | Percentage of patients affected by adverse effects of corresponding treatment (Grades 3–5) | Percentage of patients affected by adverse effects of crizotinib (Grades 3–5) | ||
| Solomon et al. 2014 [11] | Randomized clinical trial | 171 | Chemotherapy: 169 | Vision disorders | 0 | Vision disorders | 1 |
| Diarrhea | 1 | Diarrhea | 2 | ||||
| Edema | 1 | Edema | 1 | ||||
| Vomiting | 3 | Vomiting | 2 | ||||
| Constipation | 0 | Constipation | 2 | ||||
| Elevated ALT | 2 | Elevated ALT | 14 | ||||
| Headache | 1 | Headache | 1 | ||||
| Fatigue | 2 | Fatigue | 3 | ||||
| Neutropenia | 15 | Neutropenia | 11 | ||||
| Stomatitis | 1 | Stomatitis | 1 | ||||
| Leukopenia | 5 | Leukopenia | 2 | ||||
| Nausea | 2 | Nausea | 1 | ||||
| Decreased appetite | 1 | Decreased appetite | 2 | ||||
| Neuropathy | 0 | Neuropathy | 1 | ||||
| Dyspnea | 2 | Dyspnea | 3 | ||||
| Thrombocytopenia | 7 | Thrombocytopenia | 0 | ||||
| Upper respiratory infection | 0 | Upper respiratory infection | 1 | ||||
| Pyrexia | 1 | Pyrexia | 0 | ||||
| Dizziness | 1 | Dizziness | 0 | ||||
| Anemia | 9 | Anemia | 0 | ||||
| Peters et al. 2017 [12] | Randomized clinical trial | 151 | Alectinib: 152 | Nausea | 1 | Nausea | 3 |
| Diarrhea | 0 | Diarrhea | 2 | ||||
| Vomiting | 0 | Vomiting | 3 | ||||
| ALT increased | 5 | ALT increased | 15 | ||||
| AST increased | 5 | AST increased | 11 | ||||
| GGT increased | 1 | GGT increased | 1 | ||||
| Edema | 0 | Edema | 1 | ||||
| Anemia | 5 | Anemia | 1 | ||||
| Camidge et al. 2018 [13] | Randomized clinical trial | 138 | Brigatinib: 137 | Diarrhea | 1 | Diarrhea | 2 |
| Increase CK level | 16 | Increase CK level | 1 | ||||
| Nausea | 1 | Nausea | 3 | ||||
| Hypertension | 10 | Hypertension | 3 | ||||
| Increased ALT | 1 | Increased ALT | 9 | ||||
| Increased lipase level | 13 | Increased lipase level | 5 | ||||
| Vomiting | 1 | Vomiting | 2 | ||||
| Constipation | 0 | Constipation | 1 | ||||
| Increased amylase level | 5 | Increased amylase level | 1 | ||||
| Pruritis | 1 | Pruritis | 1 | ||||
| Decreased appetite | 1 | Decreased appetite | 3 | ||||
| Peripheral edema | 1 | Peripheral edema | 1 | ||||
| Upper abdominal pain | 1 | Upper abdominal pain | 1 | ||||
| Bradycardia | 1 | Bradycardia | 0 | ||||
| Pain in the extremity | 0 | Pain in the extremity | 1 | ||||
| Increase in creatinine levels | 0 | Increase in creatinine levels | 1 | ||||
| Neutropenia | 0 | Neutropenia | 4 | ||||
| Pleural effusion | 1 | Pleural effusion | 1 | ||||
| Photopsia | 0 | Photopsia | 1 | ||||