Table 7. Percentage of patients who required dose reduction due to adverse side effects.

From Camidge et al.’s randomized controlled trial [13].

Adverse side effects of all grades	Percentage of patients who required dose reduction (%)
Increased blood creatine phosphokinase	1.5
Increased alanine aminotransferase	5.8
Increased aspartate aminotransferase	0.7
Increased lipase level	0.7
Nausea	4.4
Diarrhea	2.2
Decreased appetite	1.5
Vomiting	1.5
Peripheral edema	2.2
Pneumonitis	0.7