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. 2015 Jan 8;2015(1):CD004875. doi: 10.1002/14651858.CD004875.pub5

Ruhrmann 1982.

Methods Participants were selected at the children's hospital in Hamburg, Germany. Patients were diagnosed with pneumonia based on chest X‐ray. The study compared erythromycin therapy with amoxycillin therapy. The duration of the study was not specified, nor were the inclusion and exclusion criteria. Although the treatment allocation was randomised, there was no blinding of the outcome assessor or the participant. Baseline measurements were recorded using temperature, full blood examination, chest X‐ray and cough presence. Outcome measures were noted over 10 days and were not well described, with 'clinical improvement' being documented without any clear definition
Participants
  • 120 children aged 6 months to 14 years with pneumonia. Gender ratio not stated

  • Number of children with M. pneumoniae infection in each group not stated

Interventions
  • Group A: erythromycin 70 to 80 mg/kg/day. Duration of therapy not stated

  • Group B: amoxycillin 60 to 70 mg/kg/day. Duration of therapy not stated

Outcomes Clinical presentations
Notes
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk A list of randomised numbers was used to allocate participants into treatment groups
Allocation concealment (selection bias) Unclear risk No mention of allocation concealment
Blinding (performance bias and detection bias) 
 All outcomes High risk No blinding of participants or outcome assessors
Follow‐up? 
 All outcomes Unclear risk No description of losses to follow‐up was included in the paper
Reporting of participants by allocation group? 
 All outcomes Unclear risk Unclear mention of withdrawals or drop‐outs