Comparison 5. Anticonvulsants versus placebo according to psychiatric co‐morbidity.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Dropouts	16		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
1.1 Excluding psychiatric co‐morbidity	8	1203	Risk Ratio (M‐H, Random, 95% CI)	0.85 [0.63, 1.16]
1.2 Not excluding psychiatric co‐morbidity	8	472	Risk Ratio (M‐H, Random, 95% CI)	1.08 [0.72, 1.61]
2 Heavy drinking, dichotomous outcome	5		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
2.1 Excluding psychiatric co‐morbidity	2	230	Risk Ratio (M‐H, Random, 95% CI)	0.92 [0.51, 1.68]
2.2 Not excluding psychiatric co‐morbidity	3	100	Risk Ratio (M‐H, Random, 95% CI)	0.74 [0.37, 1.45]
3 Alcohol use, continuous outcome: drinks/drinking day	11		Mean Difference (IV, Random, 95% CI)	Subtotals only
3.1 Excluding psychiatric co‐morbidity	6	823	Mean Difference (IV, Random, 95% CI)	‐1.55 [‐2.35, ‐0.75]
3.2 Not excluding psychiatric co‐morbidity	5	303	Mean Difference (IV, Random, 95% CI)	‐1.52 [‐3.51, 0.48]
4 Alcohol use, continuous outcome: heavy drinking	12		Std. Mean Difference (IV, Random, 95% CI)	Subtotals only
4.1 Excluding psychiatric co‐morbidity	5	730	Std. Mean Difference (IV, Random, 95% CI)	‐0.39 [‐0.60, ‐0.18]
4.2 Not excluding psychiatric co‐morbidity	7	399	Std. Mean Difference (IV, Random, 95% CI)	‐0.31 [‐0.58, ‐0.05]
5 Continuous abstinence, dichotomous outcome	8		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
5.1 Excluding psychiatric co‐morbidity	4	396	Risk Ratio (M‐H, Random, 95% CI)	1.12 [0.80, 1.55]
5.2 Not excluding psychiatric co‐morbidity	4	238	Risk Ratio (M‐H, Random, 95% CI)	1.37 [0.98, 1.92]
6 Abstinence, continuous outcome	10		Mean Difference (IV, Random, 95% CI)	Subtotals only
6.1 Time to first relapse (weeks): not excluding psychiatric co‐morbidity	2	108	Mean Difference (IV, Random, 95% CI)	0.26 [‐0.60, 1.13]
6.2 Days abstinent (%): excluding psychiatric co‐morbidity	3	523	Mean Difference (IV, Random, 95% CI)	9.92 [‐5.19, 25.03]
6.3 Days abstinent (%): not excluding psychiatric co‐morbidity	5	291	Mean Difference (IV, Random, 95% CI)	6.95 [‐0.37, 14.26]
7 Adverse events	11		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
7.1 Withdrawn for medical reasons: excluding psychiatric co‐morbidity	5	998	Risk Ratio (M‐H, Random, 95% CI)	1.17 [0.34, 4.00]
7.2 Withdrawn for medical reasons: not excluding psychiatric co‐morbidity	6	391	Risk Ratio (M‐H, Random, 95% CI)	1.35 [0.55, 3.29]