Paparrigopoulos 2010.

Methods	Randomised controlled open study
Participants	120 participants; mean age 46.8 years; 74.2% male; 90% Caucasian; 31% with more than 12 years of education; 57% married; 248 gr/d alcohol consumption on average Inclusion criteria: age 18 to 70 years; alcohol dependence; absence of serious physical illness; absence of another preexisting or co‐existing major psychiatric disorder on DSM‐IV Axis I; absence of abuse of another drug; participants with affective or anxiety symptoms were not excluded from the study if concurrent with an alcohol‐abusing period; however, individuals who fulfilled a DSM‐IV diagnosis of depressive or anxiety disorder were excluded from the study if such symptoms had been recorded before onset of alcoholism or during periods of abstinence
Interventions	(1) Tiagabine, 60 participants; (2) no pharmacological treatment, 60 participants Drug dose: tiagabine up to 15 to 20 mg/d Participants were involved in short‐term psychotherapy (four to six weeks) of cognitive‐behavioural orientation consisting of both individual sessions (twice a week) and family interventions (once every two weeks) Setting: inpatient for four to six weeks, then outpatient Duration: six months. Country of origin: Greece
Outcomes	Retention in treatment; abstinence from alcohol; MCV and liver enzymes; alcohol craving; mood and functioning; side effects
Notes	All participants underwent a detoxification protocol that included vitamin replacement and administration of diazepam. Tiagabine was added to the last part of the detoxification period
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No details provided
Allocation concealment (selection bias)	High risk	Unblinded study
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No details provided
Blinding of participants and personnel (performance bias) all outcomes	High risk	Unblinded study
Blinding of outcome assessment (detection bias) subjective	High risk	Unblinded study
Blinding of outcome assessment (detection bias) objective	Low risk	Outcome measurement not likely to be influenced by lack of blinding