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. 2023 Oct 19;12(10):12349. doi: 10.1002/jev2.12349

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© 2023 The Authors. Journal of Extracellular Vesicles published by Wiley Periodicals LLC on behalf of International Society for Extracellular Vesicles.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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(a) Representative cryo‐EM images of individual hCPC‐EVs (top row) and RBC‐EVs (bottom row). All scalebars are 100 nm. Several recurring structural features are visible: a high‐contrast boundary corresponding to the bilayer (red arrows), external decoration (green arrows), and occasional hints of luminal cargo (yellow arrows). (b) Top row – representative cryo‐EM images of purified LPs. All cryo‐EM scalebars are 100 nm. Compared to EVs, recurring LPs structural features include the lack of decoration and luminal cargo. Chylomicrons and VLDLs show high‐contrast boundaries (red arrows) similar in appearance to those displayed by EVs, while LDLs, IDLs and HDLs do not show any discontinuity between bulk and surface. Bottom row – representative liquid AFM images of purified LPs. All AFM scalebars are 200 nm.