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. 2023 May 29;4(1):100340. doi: 10.1016/j.xops.2023.100340

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© 2023 by the American Academy of Ophthalmology.

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Five bacterial species differ significantly over time on the ocular surface of patients with dupilumab–associated ocular surface disease (DAOSD). A–E, Box plot showing various bacterial species in patients with atopic dermatitis (AD), DAOSD, and controls identified by linear discriminant analysis. Data are presented in box and whisker plots showing minimum, maximum, and median values; a diminutive (+) indicates mean values, () gray dotted lines indicate the mean value at baseline in AD, and () orange dotted lines indicate the mean value at baseline in DAOSD. N = 3–14. One-way analysis of variance was used for statistical testing. Log10 transformation was performed to the raw values after adding a pseudo count (1). NA = not applicable.

Inline graphic — Five bacterial species differ significantly over time on the ocular surface of patients with dupilumab–associated ocular surface disease (DAOSD). A–E, Box plot showing various bacterial species in patients with atopic dermatitis (AD), DAOSD, and controls identified by linear discriminant analysis. Data are presented in box and whisker plots showing minimum, maximum, and median values; a diminutive (+) indicates mean values, () gray dotted lines indicate the mean value at baseline in AD, and () orange dotted lines indicate the mean value at baseline in DAOSD. N = 3–14. One-way analysis of variance was used for statistical testing. Log10 transformation was performed to the raw values after adding a pseudo count (1). NA = not applicable.