Figure 10.

Bacterial growth in presence of dupilumab. Acetobacter aceti and Staphylococcus aureus were cultured in different concentrations of dupilumab (2.5, 5, and 10 mg/L) and the growth was measured over a 48-hour period. A, Growth curves of A. aceti in various concentration of dupilumab. B, Area under curve (AUC) was calculated from the growth curves from 0 to 48h and data are presented in box and whisker plots showing minimum, maximum, and median values. C, Growth curves of S. aureus in various concentration of dupilumab. B, AUC was calculated from the growth curves from 0 to 48h and data are presented in box and whisker plots showing minimum, maximum, and median values. N = 8–12. One-way analysis of variance was used for statistical testing. P values are shown for respective doses vs. control. OD = optical density.