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. 1998 Sep;42(9):2456–2458. doi: 10.1128/aac.42.9.2456

TABLE 1.

Antimalarial activities of hydroxamic acidsa

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Compound and structure IC50 (μM) 95% upper bound (μM) 95% lower bound (μM) No. of tests
Aminohydroxamate (hydroxyurea) 792 >10,000 97 58
Acetohydroxamate 1,032 3,912 26.4 60
Benzohydroxamate 17.1 78.5 2.2 76
a

Hydroxyurea (Sigma), acetohydroxamate (National Cancer Institute), and benzohydroxamate (National Cancer Institute) were tested in an in vitro culture system for potential antimalarial activities according to the method of Desjardins et al. (3).