Table 5. Diagnostic performance of independent predictors and their combination for mass-forming ICC.
| Factors | AUC (95% CI) | Sensitivity (%) | Specificity (%) | Accuracy (%) | PPV (%) | NPV (%) |
|---|---|---|---|---|---|---|
| Normal AFP | 0.698 (0.604, 0.791) | 69.8 | 69.7 | 69.8 | 61.7 | 76.8 |
| Elevated CA19-9 | 0.795 (0.712, 0.877) | 77.4 | 81.6 | 79.8 | 74.5 | 83.8 |
| Targetoid sign on HBP | 0.831 (0.753, 0.910) | 75.5 | 90.8 | 84.5 | 85.1 | 84.1 |
| Targetoid restriction on DWI | 0.862 (0.791, 0.934) | 83.0 | 89.5 | 86.8 | 84.6 | 88.3 |
| Combination | 0.949 (0.905, 0.993) | 88.7 | 93.4 | 91.5 | 90.4 | 88.8 |
ICC, intrahepatic cholangiocarcinoma; AUC, area under curve; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value; AFP, alpha fetoprotein; CA19-9, carbohydrate antigen 19-9; HBP, hepatobiliary phase; DWI, diffusion-weighted imaging.