Table 2. Multivariable Analysis for Poor Outcomes.
| Factor | SHR (95% CI) | P value |
|---|---|---|
| Local recurrence (n = 12) | ||
| Sex | ||
| Female | 1 [Reference] | |
| Male | 9.82 (1.48-65.34) | .02a |
| Differentiation | ||
| Well or moderate | 1 [Reference] | |
| Poor differentiation | 2.81 (0.88-9.00) | .08 |
| PNI extent | ||
| Focal | 1 [Reference] | |
| Moderate | 2.15 (0.42-10.90) | .36 |
| Extensive | 13.83 (3.50-54.62) | <.001a |
| Any metastasis (n = 10) | ||
| Depth | ||
| Limited to dermis/subcutaneous fat | 1 [Reference] | |
| Beyond subcutaneous fat | 2.62 (0.74-9.30) | .14 |
| Differentiation | ||
| Well or moderate | 1 [Reference] | |
| Poor | 5.04 (1.28-19.84) | .02a |
| Disease-specific death (n = 11) | ||
| Age, y | 0.94 (0.88-1.01) | .12 |
| Sex | ||
| Female | 1 [Reference] | |
| Male | 8.39 (0.92-76.69) | .06 |
| PNI extent | ||
| Focal | 1 [Reference] | |
| Moderate | 1.35 (0.32-5.73) | .68 |
| Extensive | 6.20 (1.59-24.21) | .009a |
| Any poor outcome (n = 17) | ||
| Depth | ||
| Limited to dermis/subcutaneous fat | 1 [Reference] | |
| Beyond subcutaneous fat | 1.91 (0.69-5.29) | .21 |
| Sex | ||
| Female | 1 [Reference] | |
| Male | 6.86 (1.45-32.39) | .02a |
| Differentiation | ||
| Well or moderate | 1 [Reference] | |
| Poor | 3.22 (1.22-8.47) | .02a |
| PNI extent | ||
| Focal | 1 [Reference] | |
| Moderate | 1.78 (0.47-6.74) | .40 |
| Extensive | 10.21 (2.88-36.15) | <.001a |
Abbreviations: PNI, perineural invasion; SHR, subhazard ratio.
a
Statistically significant.