Table 2. Histopathologic Findings of the Biopsies During Dupilumab Treatment.

Finding	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	Patient 6	Patient 7	Patient 8	Patient 9	Patient 10	Patient 11	Patient 12	Patient 13	Patient 14
Diagnosis	LR	LR	LR	LR	LR	LR	LR	LR	LR	LR	LR	MF	MF/LR	MF
Eczematous features
Acanthosis	Moderately present	Mildly present	Severely present	Mildly present	Moderately present	Moderately present	Moderately present	Mildly present	Moderately present	Mildly present	Mildly present	Mildly present	Moderately present	Mildly present
Spongiosis	Moderately present	Mildly present	Severely present	Mildly present	Moderately present	Mildly present	Moderately present	Mildly present	Moderately present	Mildly present	Mildly present	Absent	Mildly present	Mildly present
Parakeratosis	Moderately present	Mildly present	Severely present	Mildly present	Moderately present	Mildly present	Mildly present	Moderately present	Moderately present	Mildly present	Mildly present	Mildly present	Mildly present	Moderately present
Presence of lymphoid infiltrate	Moderately present	Moderately present	Moderately present	Moderately present	Moderately present	Moderately present	Severely present	Moderately present	Severely present	Moderately present	Moderately present	Mildly present	Moderately present	Severely present
Distribution lymphoid infiltrate stratum papillare
Perivascular	Mildly present	Mildly present	Mildly present	Absent	Mildly present	Moderately present	Moderately present	Moderately present	Mildly present	Mildly present	Mildly present	Absent	Mildly present	Mildly present
Lichenoid	Moderately present	Moderately present	Moderately present	Severely present	Absent	Absent	Mildly present	Mildly present	Absent	Absent	Absent	Mildly present	Mildly present	Mildly present
Intraepithelial T-cell lymphocytes	Mildly present	Mildly present	Mildly present	Mildly present	Moderately present	Mildly present	Severely present	Moderately present	Severely present	Moderately present	Mildly present	Mildly present	Moderately present	Mildly present
Lining of cells in basal layer	Mildly present	Absent	Absent	Absent	Absent	Absent	Absent	Absent	Absent	Absent	Mildly present	Mildly present	Moderately present	Mildly present
Sprinkled pattern in epithelial layer	Moderately present	Moderately present	Moderately present	Mildly present	Moderately present	Mildly present	Moderately present	Moderately present	Mildly present	Moderately present	Moderately present	Absent	Mildly present	Absent
IHC
CD2, CD3, CD5	No loss	No loss	No loss	No loss	No loss	No loss	No loss	No loss	No loss	No loss	No loss	CD5a	CD2,a CD5a	CD2a
CD4/CD8 ratio	CD4>CD8	CD4>>>CD8	CD4>CD8	CD4>CD8	CD4<CD8	CD4>CD8	CD4<<CD8	CD4:CD8	CD4>CD8	CD4<CD8	CD4>CD8	CD4>CD8	CD4>CD8	CD4>>>CD8
CD30 expression	Mildly present	Severely present	Moderately present	Moderately present	Mildly present	Mildly present	Moderately present	Moderately present	Mildly present	Mildly present	Moderately present	Absent	Mildly present	Severely present

Abbreviations: IHC, immunohistochemical staining; LR, lymphoid reaction; MF, mycosis fungoides.

^a IHC decreased.