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. 2023 Oct 16;10(10):ENEURO.0054-23.2023. doi: 10.1523/ENEURO.0054-23.2023

Figure 3.

Figure 3.

Variable expression of tdTomato reporter in 7-week-old ΔNp73-Cre; LSL-tdTomato mice. A, Left, Representative confocal images show variable tdTomato expression in the DG between different animals at 7 weeks of age. Each image represents an individual animal. Scale bars, 200 μm. Right, Higher-magnification images show CR cells (white arrows) and dentate gyrus granule neurons (yellow arrows). Scale bars, 50 μm. B. Representative confocal images show variable tdTomato expression between the two hemispheres of a 4-week-old and a 7-week-old animal. Yellow arrows point to granule neurons. Quantification of the variation indexes (the difference of cell densities between the two hemispheres divided by the sum of the cell densities) is shown at the bottom. Between the two hemispheres of 7-week-old animals, tdTomato expression in granule neurons is significantly more variable than that in CR cells. Data are presented as scatter plots with all data points shown and error bars representing ±SD. Each data point is an individual animal, whereby three sections were measured for each animal. Statistical analyses were performed using Welch’s t test. *p < 0.05. SLM, Stratum lacunosum-moleculare; HF, hippocampal fissure; ML, molecular layer; GL, granular layer.