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. 2023 Oct 10;101(15):e1542–e1553. doi: 10.1212/WNL.0000000000207726

Figure 2. Association of LATE-NC With Respiratory Muscle Strength Decline.

Figure 2

Panels A and B illustrate raw trajectories of respiratory muscle strength assessments in 50 randomly selected participants without (A) and with (B) LATE-NC stages 2–3. The overlaid black line shows the average trajectory of respiratory muscle strength decline in these participants derived from mixed-effect models. Panel C illustrates the trajectories of respiratory muscle strength decline in 3 average 90-year-old women derived from a mixed-effect model: a woman without significant brain pathologies (the solid gray line), a woman with only LATE-NC stages 2–3 (the dotted black line), and a woman with all the brain pathologies (the solid black line). LATE-NC = neuropathologic changes of limbic-predominant age-related TDP-43 encephalopathy; TDP-43 = transactive response DNA-binding protein 43.