. 2023 Oct 10;101(15):e1531–e1541. doi: 10.1212/WNL.0000000000207706

Table 4.

Area Under the Receiver Operating Characteristic Curve (AUROC) for Serum GFAP for Diagnostic Classifications

	Cognitively unimpaired vs dementia			Mild cognitive impairment vs dementia			Cognitively unimpaired vs mild cognitive impairment
	All participants	MA participants	NHW participants	All participants	MA participants	NHW participants	All participants	MA participants	NHW participants
Model 1	0.886 (0.866–0.905) p < 0.001^a	0.858 (0.821–0.895) p < 0.001^a	0.777 (0.733–0.820) p < 0.001^a	0.840 (0.814–0.866) p < 0.001^a	0.734 (0.684–0.784) p < 0.001^a	0.803 (0.775–0.850) p < 0.001^a	0.635 (0.603–0.668) p < 0.001^a	0.673 (0.637–0.709) p < 0.001^a	0.485 (0.415–0.556) p = 0.683
Group contrasts		Z = 2.780, p = 0.005^a			Z = 1.962, p = 0.050			Z = −4.633, p < 0.001^a
Model 2	0.909 (0.892–0.926) p < 0.001^a	0.851 (0.813–0.889) p < 0.001^a	0.847 (0.808–0.887) p < 0.001^a	0.844 (0.819–0.870) p < 0.001^a	0.751 (0.702–0.800) p < 0.001^a	0.799 (0.752–0.847) p < 0.001^a	0.698 (0.668–0.728) p < 0.001^a	0.738 (0.705–0.771) p < 0.001^a	0.519 (0.448–0.590) p = 0.600
Group contrasts		Z = −0.155, p = 0.877			Z = 1.392, p = 0.164			Z = −5.473, p < 0.001^a
Model 3	0.921 (0.905–0.937) p < 0.001^a	0.859 (0.823–0.895) p < 0.001^a	0.887(0.854–0.921) p < 0.001^a	0.854 (0.829–0.879) p < 0.001^a	0.770 (0.723–0.817) p < 0.001^a	0.808 (0.761–0.856) p < 0.001^a	0.709 (0.679–0.739) p < 0.001^a	0.740 (0.707–0.773) p < 0.001^a	0.570 (0.500–0.639) p = 0.051
Group contrasts		Z = 1.117, p = 0.264			Z = 1.121, p = 0.262			Z = −4.315, p < 0.001^a

Abbreviations: GFAP = glial fibrillary acidic protein, MA = Mexican American, NHW = non-Hispanic White.

Area under the receiver operating characteristic curve (95% Confidence Intervals) of serum GFAP for diagnostic classification across the whole sample and with stratification for ethnicity.

Model 1 = adjusts for site; Model 2 = adjusts for site, age, and sex, Model 3 = adjusts for site, age, sex, body mass index, diabetes, tobacco use, and Apolipoprotein E ε4 allele.

p < 0.05 level of significant for assessing ethnic differences.