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. 2023 Oct 10;101(15):e1531–e1541. doi: 10.1212/WNL.0000000000207706

Table 5.

Optimal Cut Points for Diagnostic Classification Derived by the Maximum Kolmogorov-Smirnov Metric

graphic file with name WNL-2023-000498t5.jpg

Cognitively unimpaired vs dementia Mild cognitive impairment vs dementia Cognitively unimpaired vs mild cognitive impairment
All participants MA participants NHW participants All participants MA participants NHW participants All participants MA participants NHW participants
Model 1 0.409 (0.754–0.882) 0.243 (0.579–0.836) 0.624 (0.806–0.801) 0.541 (0.745–0.807) 0.346 (0.586–0.755) 0.776 (0.686–0.802) 0.360 (0.485–0.744) 0.329 (0.608–0.677) 0.353 (0.541–0.534)
Model 2 0.356 (0.829–0.857) 0.198 (0.771–0.818) 0.487 (0.921–0.646) 0.563 (0.727–0.819) 0.299 (0.686–0.707) 0.755 (0.730–0.757) 0.307 (0.718–0.598) 0.321 (0.662–0.709) 0.527 (0.306–0.795)
Model 3 0.438 (0.813–0.898) 0.141 (0.821–0.775) 0.546 (0.908–0.731) 0.555 (0.756–0.828) 0.283 (0.707–0.701) 0.617 (0.895–0.568) 0.295 (0.744–0.572) 0.306 (0.697–0.664) 0.517 (0.369–0.769)

Abbreviations: MA = Mexican American, NHW = non-Hispanic White.

Note: Optimal cut points for diagnostic classification derived by the maximum Kolmogorov-Smirnov metric (sensitivity, specificity) across the whole sample and with stratification for ethnicity.

Model 1 = adjusts for site; Model 2 = adjusts for site, age, and sex; Model 3 = adjust for site, age, sex, body mass index, diabetes, tobacco use, and Apolipoprotein E ε4 allele.