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. 2023 Oct 10;101(15):e1521–e1530. doi: 10.1212/WNL.0000000000207700

Table 3.

Primary and Secondary Analyses of Subcortical Atrophy (CC/IT Ratio), N = 1,102

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<25th percentile (n = 276) 25th–50th percentile (n = 281) 50th–75th percentile (n = 273) 75th–100 percentile (n = 272) a/cOR (95% CI)a p Value
90-d mRS, median (IQR) 1 (1–2) 2 (1–4) 2 (1–4) 3 (2–5) 1.07 (1.04–1.11) <0.001
90-d mRS 0–2, n/N (%) 209/276 (75) 175/281 (62) 158/273 (58) 123/272 (45) 0.92 (0.88–0.97) 0.001
90-d mRS 6, n/N (%) 24/276 (9) 30/281 (11) 34/273 (12) 57/272 (21) 1.06 (0.99–1.13) 0.10

Abbreviations: a/cOR = adjusted/common odds ratio; CC/IT ratio = intercaudate distance to inner table width ratio; CI = confidence interval; GCA = global cortical atrophy; NIHSS = National Institutes of Health Stroke Scale; WMD = white matter disease.

Adjustments were made for age, sex, final infarct volume, total WMD-burden, the interaction between alteplase and nerinetide, NIHSS at baseline, stroke laterality, and presence of chronic infarctions. Quartile distribution, see methods.

a

The CC/IT ratio is included as a full continuous scale in the regression analyses.