Table 3.
<25th percentile (n = 276) | 25th–50th percentile (n = 281) | 50th–75th percentile (n = 273) | 75th–100 percentile (n = 272) | a/cOR (95% CI)a | p Value | |
90-d mRS, median (IQR) | 1 (1–2) | 2 (1–4) | 2 (1–4) | 3 (2–5) | 1.07 (1.04–1.11) | <0.001 |
90-d mRS 0–2, n/N (%) | 209/276 (75) | 175/281 (62) | 158/273 (58) | 123/272 (45) | 0.92 (0.88–0.97) | 0.001 |
90-d mRS 6, n/N (%) | 24/276 (9) | 30/281 (11) | 34/273 (12) | 57/272 (21) | 1.06 (0.99–1.13) | 0.10 |
Abbreviations: a/cOR = adjusted/common odds ratio; CC/IT ratio = intercaudate distance to inner table width ratio; CI = confidence interval; GCA = global cortical atrophy; NIHSS = National Institutes of Health Stroke Scale; WMD = white matter disease.
Adjustments were made for age, sex, final infarct volume, total WMD-burden, the interaction between alteplase and nerinetide, NIHSS at baseline, stroke laterality, and presence of chronic infarctions. Quartile distribution, see methods.
The CC/IT ratio is included as a full continuous scale in the regression analyses.