Table 2.
Distribution of clinicopathological characteristics regarding different CNV cut-off values in tumor tissue
| Characteristic | Group | N | MYC ≥ 2.10A (N = 58, 50.9%) | MYC < 2.10A (N = 56, 49.1%) | p-value (chi2 test) | TERT ≥ 2.27B (N = 47, 41.2%) | TERT < 2.27B (N = 67, 58.8%) | p-value (chi2 test) |
|---|---|---|---|---|---|---|---|---|
| Age | ≤ 70 years | 62 | 31 (53.5) | 31 (55.4) | 0.8379 | 24 (51.1) | 38 (56.7) | 0.5509 |
| > 70 years | 52 | 27 (46.6) | 25 (44.6) | 23 (48.9) | 29 (43.3) | |||
| Sex | Female | 57 | 22 (37.9) | 35 (62.5) | 0.0087 | 21 (44.7) | 36 (53.7) | 0.3414 |
| Male | 57 | 36 (62.1) | 21 (37.5) | 26 (55.3) | 31 (46.3) | |||
| Smoking status | Never | 17 | 6 (10.3) | 11 (19.6) | 0.3230* | 6 (12.8) | 11 (16.4) | 0.0590* |
| Former | 41 | 21 (36.2) | 20 (35.7) | 12 (25.5) | 29 (43.9) | |||
| Current | 54 | 29 (50.0) | 25 (44.6) | 27 (57.5) | 27 (40.3) | |||
| Missing | 2 | 2 (3.5) | 0 (0.0) | 2 (4.3) | 0 (0.0) | |||
| Histological subtypes | Lung adenocarcinoma | 74 | 36 (62.1) | 38 (67.9) | 0.2827 | 30 (63.8) | 44 (65.7) | 0.5670 |
| Lung squamous cell carcinoma | 27 | 17 (29.3) | 10 (17.9) | 13 (27.7) | 14 (20.9) | |||
| Other | 13 | 5 (8.6) | 8 (14.3) | 4 (8.5) | 9 (13.4) | |||
| Grade | G1 + G2 | 55 | 24 (41.4) | 31 (55.4) | 0.0399 | 23 (48.9) | 32 (47.8) | 0.6515 |
| G3 | 52 | 33 (56.9) | 19 (33.9) | 24 (51.1) | 28 (41.8) | |||
| GX§ | 7 | 1 (1.7) | 6 (10.7) | 0 (0.0) | 7 (10.5) | |||
| T Stage | T1 | 43 | 22 (37.9) | 21 (37.5) | 0.6470 | 15 (31.9) | 28 (41.8) | 0.3371 |
| T2 | 39 | 23 (39.7) | 16 (28.6) | 18 (38.3) | 21 (31.3) | |||
| T3 + T4 | 27 | 13 (22.4) | 14 (25.0) | 14 (29.8) | 13 (19.4) | |||
| TX$ | 5 | 0 (0.0) | 5 (8.9) | 0 (0.0) | 5 (7.5) |
Acut-off value for MYC at 99% specificity and 51% sensitivity
Bcut-off value for TERT at 99% specificity and 41% sensitivity
§GX was excluded from tests
$TX was excluded from tests
*p-value from Fisher’s exact test