Table 5.

Results of the group-wise LMM analysis performed to evaluate change in parieto-occipital EEG measures over time (in months) in Aβ + MCI or AD dementia patients. Regression coefficients (β) and 95% confidence intervals (CI) of the Time effects are reported. Estimates for the Group*Time interaction effects, as well as estimates adjusted for age, sex and medication use are presented in Additional file 2 (Table S4)

Region	Measure	Frequency band	Disease stage	β	95% CI		p-value
Parieto-occipital	Relative power	Theta	MCIb	1.6E-03	8.3E-04	2.3E-03	< .001***
			AD dementiab	8.7E-04	-2.0E-04	1.9E-03	0.12
		Alpha1	MCIa	3.8E-04	-1.1E-03	1.9E-03	0.62
			AD dementiaa	-1.2E-03	-3.0E-03	5.2E-04	0.17
		Alpha2	MCIa	-1.3E-04	-1.5E-03	1.2E-03	0.86
			AD dementiaa	-4.5E-04	-2.0E-03	1.1E-03	0.58
		Beta	MCIa	-1.0E-03	-1.8E-03	-2.7E-04	< .01**
			AD dementiaa	-5.0E-04	-1.4E-03	3.9E-04	0.27
	Peak frequency	-	MCIa	-1.0E-02	-2.1E-02	1.2E-03	0.08
			AD dementiaa	-2.3E-02	-3.6E-02	-9.6E-03	< .001***
	AEC-c	Alpha	MCIa	-1.5E-04	-6.1E-04	3.1E-04	0.53
			AD dementiaa	2.1E-05	-5.1E-04	5.5E-04	0.94
		Beta	MCIa	-7.1E-05	-2.4E-04	9.9E-05	0.41
			AD dementiaa	-1.2E-04	-3.2E-04	7.5E-05	0.22
	PLI	Theta	MCIa	1.9E-04	-3.4E-04	7.2E-04	0.48
			AD dementiaa	2.1E-04	-4.1E-04	8.3E-04	0.50
	PE	Theta	MCIa	-2.4E-05	-2.5E-04	2.0E-04	0.84
			AD dementiaa	-2.0E-04	-4.6E-04	6.4E-05	0.14
	wSMI	Theta	MCIa	-1.8E-05	-1.9E-04	1.5E-04	0.83
			AD dementiaa	1.4E-04	-5.2E-05	3.4E-04	0.15
	JPEinv	Theta	MCIa	7.6E-07	-1.4E-04	1.4E-04	0.99
			AD dementiaa	-1.3E-04	-2.9E-04	3.6E-05	0.13

AEC-c Corrected amplitude envelope correlation, PLI Phase lag index, PE Permutation entropy, wSMI Weighted symbolic mutual information, JPE_inv Inverted joint permutation entropy

*p<.05, **p<.01, ***p<.001

^aRandom intercept on subject level

^bRandom intercept and random slope on subject level