Table 6.

Results of the group-wise LMM analysis performed to evaluate change in temporal EEG measures over time (in months) in Aβ + MCI or AD dementia patients. Regression coefficients (β) and 95% confidence intervals (CI) of the Time effects are reported. Estimates for the Group*Time interaction effects, as well as estimates adjusted for age, sex, and medication use are presented in Additional file 2 (Table S5)

Region	Measure	Frequency band	Disease stage	β	95% CI		p-value
Temporal	Relative power	Theta	MCIb	2.2E-03	1.2E-03	3.1E-03	< .001***
			AD dementiab	8.2E-04	-3.1E-04	2.0E-03	0.16
		Alpha1	MCIb	-3.7E-04	-1.3E-03	5.6E-04	0.44
			AD dementiab	-6.0E-04	-1.7E-03	5.0E-04	0.30
		Alpha2	MCIa	-2.5E-04	-8.4E-04	3.4E-04	0.41
			AD dementiaa	-5.7E-04	-1.3E-03	1.1E-04	0.10
		Beta	MCIa	-8.0E-04	-1.4E-03	-1.8E-04	< .05*
			AD dementiaa	-5.8E-04	-1.3E-03	1.5E-04	0.12
	AEC-c	Alpha	MCIa	-1.6E-04	-5.8E-04	2.7E-04	0.47
			AD dementiaa	-2.2E-05	-5.1E-04	4.7E-04	0.93
		Beta	MCIa	-2.5E-05	-1.9E-04	1.4E-04	0.77
			AD dementiaa	-5.2E-05	-2.5E-04	1.4E-04	0.60
	PLI	Theta	MCIa	1.1E-04	-3.7E-04	5.8E-04	0.66
			AD dementiaa	1.5E-04	-4.0E-04	7.1E-04	0.59
	PE	Theta	MCIa	-9.2E-05	-3.0E-04	1.2E-04	0.39
			AD dementiaa	-2.5E-04	-4.9E-04	-7.6E-06	< .05*
	wSMI	Theta	MCIa	1.5E-05	-1.4E-04	1.7E-04	0.85
			AD dementiaa	1.5E-04	-2.8E-05	3.4E-04	0.10
	JPEinv	Theta	MCIa	-5.0E-05	-1.7E-04	6.7E-05	0.40
			AD dementiaa	-1.3E-04	-2.7E-04	6.9E-06	0.06

AEC-c Corrected amplitude envelope correlation, PLI Phase lag index, PE Permutation entropy, wSMI Weighted symbolic mutual information, JPE_inv Inverted joint permutation entropy

*p<.05, **p<.01, ***p<.001 

^aRandom intercept on subject level

^bRandom intercept and random slope on subject level