Table 7.

Results of the group-wise LMM analysis performed to evaluate change in global EEG measures over time (in months) in Aβ + MCI or AD dementia patients. Regression coefficients (β) and 95% confidence intervals (CI) of the Time effects are reported. Estimates for the Group*Time interaction effects, as well as estimates adjusted for age, sex and medication use are presented in Additional file 2 (Table S6)

Region	Measure	Frequency band	Disease stage	β	95% CI		p-value
Global	Relative power	Theta	MCIb	1.8E-03	1.1E-03	2.6E-03	< .001***
			AD dementiab	9.3E-04	-4.6E-05	1.9E-03	0.07
		Alpha1	MCIb	-2.4E-04	-1.3E-03	7.8E-04	0.64
			AD dementiab	-9.9E-04	-2.2E-03	1.8E-04	0.10
		Alpha2	MCIa	-1.9E-04	1.0E-03	6.2E-04	0.64
			AD dementiaa	-4.8E-04	-1.4E-03	4.6E-04	0.32
		Beta	MCIa	-7.0E-04	-1.3E-03	-5.1E-05	< .05*
			AD dementiaa	-3.2E-04	-1.1E-03	4.3E-04	0.40
	AEC-c	Alpha	MCIa	-1.7E-04	-5.9E-04	2.5E-04	0.42
			AD dementiaa	1.3E-05	-4.7E-04	5.0E-04	0.96
		Beta	MCIa	-3.4E-05	-1.9E-04	1.2E-04	0.67
			AD dementiaa	-9.1E-05	-2.7E-04	9.3E-05	0.33
	PLI	Theta	MCIa	1.3E-04	-3.2E-04	5.8E-04	0.58
			AD dementiaa	1.8E-04	-3.5E-04	7.0E-04	0.50
	PE	Theta	MCIa	-5.5E-05	-2.6E-04	1.5E-04	0.60
			AD dementiaa	-2.3E-04	-4.6E-04	1.2E-05	0.06
	wSMI	Theta	MCIa	2.9E-06	-1.5E-04	1.6E-04	0.97
			AD dementiaa	1.5E-04	-3.3E-05	3.3E-04	0.11
	JPEinv	Theta	MCIa	-5.6E-06	-1.4E-04	1.3E-04	0.93
			AD dementiaa	-1.2E-04	-2.8E-04	3.4E-05	0.12

AEC-c Corrected amplitude envelope correlation, PLI Phase lag index, PE Permutation entropy, wSMI Weighted symbolic mutual information, JPE_inv Inverted joint permutation entropy

*p<.05, **p<.01, ***p<.001

^aRandom intercept on subject level

^bRandom intercept and random slope on subject level