Table 9.
Required sample sizes (per arm) to detect different treatment effects on EEG outcome measures in Aβ + AD patients (MCI and AD dementia) in a hypothetical trial of 1- or 2-year duration, at 80% power
| Subjects | Region | Frequency band | Measure | Sample size (50% less deterioration) | Sample size (stabilization) | Sample size (50% improvement) | |||
|---|---|---|---|---|---|---|---|---|---|
| 1 year | 2 years | 1 year | 2 years | 1 year | 2 years | ||||
| Whole-group (MCI and AD dementia) | Temporal | Theta | Relative power | 1023 | 235 | 235 | 62 | 108 | 28 |
| Parieto-occipital | - | Peak frequency | 2525 | 551 | 551 | 139 | 257 | 62 | |
| Temporal | Beta | Relative power | 3436 | 860 | 860 | 216 | 383 | 102 | |