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. 2023 Oct 19;42:270. doi: 10.1186/s13046-023-02820-z

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — UGDH expression in ovarian cancer histotypes. Representative images of UGDH expression in high grade serous ovarian cancers that were scored as (A) Negative, B Low, C Moderate or (D) Strong, for both cytoplasmic and nuclear localization. E Proportions of staining scores for cytoplasmic and nuclear expression of UGDH in primary tumors and (F) metastases. G Survival analysis of HGS cancers comparing low versus high cytoplasmic UGDH. H Survival analysis of HGS cancers comparing low versus high nuclear UGDH. I Progression-free survival analysis of HGS cancers comparing low versus high cytoplasmic UGDH. J Progression-free survival analysis of HGS cancers comparing low versus high nuclear UGDH. K Clear cell, Stage 3C, top left panel H&E in 4X, top right panel IHC in 4X, lower panel IHC 20x, L Endometrioid, stage 3C, top left panel H&E in 4X, top right panel IHC in 4X, lower panel IHC 20x. M Mucinous Stage 3C top left panel H&E in 4X, top right panel IHC in 4X, lower panel IHC 20x. N Expression of UGDH expressed as H-score. Scale bar is 200 µm