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. 2023 Oct 19;42:270. doi: 10.1186/s13046-023-02820-z

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Effects of UGDH knockdown in C1/MES cell lines, and over-expression in C4/DIF cell lines on TIC populations and functions in vitro. Colony forming capacity of C1/MES cell lines with UGDH knockdown (sh459, sh939) compared to control (shneg) in: A OV90, B HEYA8. Colony-forming capacity in of C4/DIF cell lines with control (VC) and UGDH overexpression (OverX): C ACI23, D SKOV3. Quantification of the proportion of CD133 + ALDH + cells in C1/MES cell lines with UGDH knockdown (sh459, sh939) compared to control (shneg) in: E OV90 and (F) HEYA8. Quantification of the proportion of CD133 + ALDH + population in C4/DIF cell lines with control (VC) and UGDH overexpression (OverX) in (G) ACI23, H SKOV3. Analysis of cell death by AnnexinV and PI double positive cell population from in vitro relapse model in spheroids generated from viable cells collected after 48 h of carboplatin treatment followed by induction of UGDH silencing (sh459, sh939) compared to control (shneg) in C1/MES cells (I) OV90, J HEYA8 or with UGDH overexpression (OverX) or control (VC) in C4/DIF cell lines in (K) ACI23, L SKOV3. n.s non-significant, *p < 0.05, **p < 0.01, ***p < 0.001