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Lung tissue burden of A. fumigatus. Mice were infected with a sublethal inoculum of 4.5 × 104 CFU and treated with SCH56592 at 25 mg/kg/dose, GCSF at 125 μg/kg/dose, or both (Comb). With this regimen SCH56592 alone and combined therapy reduced the counts in lung tissue significantly more than no treatment did. Combined therapy was not superior to SCH56592 alone.
