Table 2.

Comparison of the performance of different estimation methods of the effect of cumulative exposure to psychosocial stressors at work on blood pressure in the nonparametric plasmode simulation scenario

	Intermittent	Cessation	Onset	Chronic
Bias
IPTW	-0.51	0.04	-0.38	-0.34
g-computation	-0.59	-0.42	-0.39	-0.14
TMLE	-0.20	-0.75	-0.02	-0.91
TMLE+SL	-0.24	-0.73	-0.05	-0.90
Baseline adjustment	-0.94	-0.77	0.58	-0.90
Baseline and Time-varying covariates adjustment	-0.88	-0.82	0.04	-1.08
Standard deviation
IPTW	1.02	1.49	1.16	2.93
g-computation	0.49	0.80	0.66	0.98
TMLE	0.90	0.84	0.63	1.43
TMLE+SL	0.90	0.84	0.63	1.42
Baseline adjustment	0.65	0.89	0.64	1.45
aseline and Time-varying covariates adjustment	0.65	0.85	0.70	1.50
RMSE
IPTW	1.14	1.49	1.22	2.95
g-computation	0.77	0.90	0.77	0.99
TMLE	0.92	1.12	0.63	1.70
TMLE+SL	0.93	1.12	0.64	1.68
Baseline adjustment	1.14	1.15	0.90	1.75
Baseline and Time-varying covariates adjustment	1.09	1.21	0.65	1.81
Coverage of the 95% confidence interval
IPTW	94%	91%	93%	71%
g-computation	73%	89%	89%	92%
TMLE	93%	83%	94%	86%
TMLE+SL	93%	83%	94%	87%
Baseline adjustment	70%	74%	80%	67%
Baseline and Time-varying covariates adjustment	71%	69%	93%	65%

Legend: IPTW = Inverse probability of treatment weighting, RMSE = root mean squarred error, SL = Super Learner, TMLE = Targeted maximum likelihood