TABLE 3.

Comparison of compartmental (plasma) and noncompartmental (plasma, saliva) pharmacokinetic parameters of moxifloxacin^a

Compartment, dose (mg), and model	AUC (mg · h/liter)	AUCnorm (kg · h/liter)	Cmax (mg/liter)	Cmax,norm (kg/liter)	Tmax (h)	t1/2 (h)	Mean residence time (h)	CL/F (ml/min)	CLR (ml/min)b	Aeur (%)	V/F (liters)c
Plasma, 200
Noncompartmental model	15.4/1.20	6.13/1.13	1.16/1.35	0.46/1.27	1.96/1.69	14.0/1.14	17.0/1.11	217/1.20	44/1.25	19.8/1.16	264/1.14
Two-compartmental model	15.3/1.19	6.11/1.12	1.15/1.38	0.46/1.30	1.66/1.74	11.8/1.25	16.2/1.16	218/1.19	—d	—	222/1.15
Saliva
200	14.0/1.29	5.60/1.27	1.62/1.44	0.65/1.40	1.89/1.62	12.4/1.29	14.8/1.14	238/1.29	—	—	254/1.34
100	8.27/1.54	6.01/1.49	0.84/1.74	0.61/1.77	1.98/1.78	12.0/1.19	18.3/1.12	202/1.54	—	—	216/1.57
50	2.81/1.40	4.72/1.37	0.31/1.55	0.53/1.56	1.45/1.57	12.0/1.29	16.5/1.31	297/1.40	—	—	308/1.36

^aData were obtained after the administration of a 200-mg single dose and, for saliva, after the administration of single 50- and 100-mg doses. Data are geometric mean/SD 

^bCL_R, renal clearance. 

^cV/F, volume of distribution during the terminal phase. 

^d—, not applicable.