Table 12. hMAO Inhibition Property of Donepezil–Butylated Hydroxytoluene (BHT) Hybrids.

compound	R	IC50 for MAO-A (μM)	IC50 for MAO-B (μM)	SI valuea
139	H	62.3 ± 3.1	8.5 ± 0.3	7.329
140	4-OCH3	72.5 ± 5.1	6.7 ± 1.2	10.820
141	2-CH3	69.3 ± 3.2	7.2 ± 0.2	9.625
142	3-CH3	70.1 ± 0.1	8.9 ± 0.3	7.876
143	2-F	60.2 ± 0.4	7.4 ± 0.2	8.135
144	3-F	58.4 ± 0.5	6.5 ± 0.2	8.984
145	4-F	59.6 ± 0.4	11.1 ± 0.1	5.369
146	2,4–2F	70.6 ± 0.3	12.5 ± 1.1	5.648
147	3,4–2F	64.5 ± 1.2	9.3 ± 0.2	6.935
148	2-Cl	72.1 ± 2.2	9.8 ± 0.2	7.357
149	3-Cl	65.1 ± 2.3	8.7 ± 0.1	7.482
150	4-Br	73.2 ± 1.1	13.2 ± 1.2	5.545
151	3-NO2	70.9 ± 1.4	12.5 ± 1.1	5.672
152	4-CN	78.2 ± 1.3	13.9 ± 0.3	5.625

^aSelectivity index for MAO-B (IC₅₀ for MAO-A/IC₅₀ for MAO-B).