Table 4. rMAO Inhibitory Activity of para-Substituted 4-Phenylpiperidines and 4-Phenylpiperazines.

compound	X	R	pKi (MAO-A) (mM)	pKi (MAO-B) (mM)
22	–CH	–H	5.01	NT
23	–CH	–Cl	5.82	4.42
24	–CH	–CF3	5.16	4.89
25	–CH	–morpholine	5.92	4.89
26	–CH	–OMe	6.62	3.66
27	–CH	–O-n-Bu	6.43	5.80
28	–CH	–CN	4.03	3.23
29	–CH	–SO2Me	3.23	3.23
30	–N	–H	4.33	NT
31	–N	–OMe	5.85	3.23
32	–N	–OSO2CF3	4.77	7.48

^ap_K: negative logarithm of binding affinities. NT: not tested.