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. 2023 Oct 3;8(41):37731–37751. doi: 10.1021/acsomega.3c05883

Table 5. Rat Liver Mitochondrial MAO (rMAO) Enzyme Inhibitory Activity of Donepezil–N-[(5-Benzyloxy-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine Hybrids.

4.

compound X Y n IC50 for MAO-A (μM) IC50 for MAO-A (μM) SI valuea
33 N CH 0 0.082 ± 0.003 0.750 ± 0.0020 0.1093
34 N CH 1 0.0067 ± 0.0018 0.130 ± 0.041 0.0515
35 N CH 2 0.0052 ± 0.0011 0.043 ± 0.008.0 0.1209
36 N CH 3 0.010 ± 0.0040 2.700 ± 0.110 0.00370
37 CH N 1 0.140 ± 0.044 1.400 ± 0.500 0.1
38 CH N 2 0.065 ± 0.017 11.000 ± 2.400 0.0059
39 N N 2 0.031 ± 0.014 1.600 ± 0.710 0.0193
a

Selectivity index for MAO-B (IC50 for MAO-A/IC50 for MAO-B).