Table 7. Rat Liver-Isolated MAO (rMAO) Inhibitory Activity of Donepezil–Propargylamine–8-Hydroxyquinoline Derivatives.

compound	X	n	IC50 for MAO-A (μM)	IC50 for MAO-B (μM)	SI valuea
56	H	0	≥100	≥100	1
57	CN	1	22.1 ± 0.7	39.5 ± 1.4	0.559
58	H	1	85.4 ± 3.7	19.4 ± 3.2	4.402
59	CN	2	9.7 ± 1.5	12.4 ± 2.5	0.782
60	H	2	≥100	50.1 ± 5	1.996
61	CN	3	6.2 ± 0.7	10.2 ± 0.9	0.607
62	H	3	≥100	34.5 ± 3.5	2.898

^aSelectivity index for MAO-B (IC₅₀ for MAO-A/IC₅₀ for MAO-B).