Table 9. Inhibitory Activity of hMAO Isoenzymes by Donepezil–Coumarin Hybrids.

compound	R1	R2	n	m	IC50 for MAO-B (μM)
73	H	H	2	0	8.39 ± 0.91
74	H	H	3	0	12.6 ± 1.2
75	H	H	2	2	30.4 ± 2.5
76	H	Me	2	0	2.75 ± 0.22
77	H	Cl	2	0	33.9 ± 2.1
78	H	OMe	2	0	33.6 ± 0.9
79	H	OEt	2	0	31.9 ± 1.9
80	H	CF3	2	0	28.5 ± 1.7
81	H	Ph	2	0	45.6 ± 3.6
82	Me	H	2	0	2.38 ± 0.11
83	Me	Me	2	0	23.4 ± 1.1
84	Cl	Me	2	0	14.7 ± 1.5
85	–(CH2)4–		2	0	2.62 ± 0.81
86	H	Me		0	1.93 ± 0.33
87	H	Me		2	40.5 ± 4.1