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. 2023 Apr 7;26(10):655–668. doi: 10.1093/ijnp/pyad017

Figure 4.

Figure 4.

Co-administration with the pharmacological inhibitors of the mammalian target of rapamycin complex 1 (mTORC1) signaling cascade notably attenuated the antidepressant actions of vortioxetine in the chronic social defeat stress (CSDS) model. (A) Detailed schematic timeline of the experimental design is provided. (B) I.c.v. infusion of LY294002, U0126, and rapamycin all significantly blocked the downregulating effects of vortioxetine on the immobility of mice subjected to CSDS in the FST (n = 10). (C) I.c.v. infusion of LY294002, U0126, and rapamycin also blocked the downregulating effects of vortioxetine on the immobility of mice subjected to CSDS in the TST (n = 10). (D) Co-administration with LY294002, U0126, and rapamycin all attenuated the promoting effects of vortioxetine on the sucrose preference of mice subjected to CSDS (n = 10). (E) Co-administration with LY294002, U0126, and rapamycin also attenuated the promoting effects of vortioxetine on the social interaction of mice subjected to CSDS (n = 10). The data are expressed as means ± SEM, **P < .01. The comparisons were made by 1-way ANOVA followed by post-hoc Tukey test.